Non-coding RNAs; microRNAs; piwiRNAs; lncRNAs; circularRNAs; extracellular vesicles; exosomes; biomarkers; lung cancer; colorectal cancer; lymphoma; leukemia; Hodgkin lymphoma; Multiple myeloma; organoids;
Below we have included selected papers describing some of our best known work.
-Diagnostic and Prognostic Value of hsa_piR_022710, hsa_piR_019822, and hsa_piR_020840 in Early-Stage Non-Small-Cell Lung Cancer: Implications for Recurrence and Survival in Squamous Cell Carcinoma Patients Yangyi He, Antonio Altuna-Coy, Melissa Acosta-Plasencia, Laureano Molins, David Sánchez-Lorente, Daniel Martinez, Tania Díaz, Risha Na, Ramón M. Marrades and Alfons Navarro Int. J. Mol. Sci. 2025, 26(7), 2870.
-Selection of the Most Suitable Culture Medium for Patient-Derived Lung Cancer Organoids. M Acosta-Plasencia, Y He, D Martínez, JP Orozco, A Carrasco, A Altuna-Coy, T Yang, T Díaz, L Molins, R Ramos, RM Marrades, A Navarro. Cells Tissues Organs. 2024 September 5:1-21.
-Discovering genes and microRNAs involved in human lung development unveils IGFBP3/miR-34a dynamics and their relevance for alveolar differentiation. M Acosta-Plasencia, JJ Castellano, T Diaz, Y He, RM Marrades, A Navarro. Stem Cell Research & Therapy. 2024 August 26;15(1):263.
-Analysis of tumor-draining vein secretome: A direct access to tumor-derived extracellular vesicles in surgical lung cancer patients. Y He, D Sanchez-Lorente, M Acosta-Plasencia, …, A Navarro. Biocell. 2023 April 10;47(5):951-957.
-Characterization of the MicroRNA Cargo of Extracellular Vesicles Isolated from a Pulmonary Tumor-Draining Vein Identifies miR-203a-3p as a Relapse Biomarker for Resected Non-Small Cell Lung Cancer. B Han, L Molins, Y He, …, A Navarro. Int J Mol Sci. 2022 Jun 27;23(13):7138.
-Human embryonic mesenchymal lung-conditioned medium promotes differentiation to myofibroblast and loss of stemness phenotype in lung adenocarcinoma cell lines. J Canals, A Navarro, C Vila, … J Exp Clin Cancer Res. 2022 Jan 26;41(1):37.
-Epigenetic regulation mechanisms of microRNA expression. S Morales, M Monzo, A Navarro. Biomolecular concepts 8 (5-6), 203-212.
-Non-coding RNAs in Hodgkin lymphoma. A Cordeiro, M Monzó, A Navarro. International journal of molecular sciences 18 (6), 1154.
-MIR135A1 (microRNA 135a-1). A Navarro, M Díaz-Beyá, M Monzó. Atlas of Genetics and Cytogenetics in Oncology and Haematology.
-MicroRNAs in human embryonic and cancer stem cells. A Navarro, M Monzó. Yonsei medical journal 51 (5), 622-632.
-Pharmacogenomics: a tool for improving cancer chemotherapy. M Monzo, A Navarro, G Ferrer, R Artells. Clinical and Translational Oncology 10 (10), 628-637.
-Editorial: Evolving roles of piRNAs in solid tumors. Ng L, Navarro A and Law W-L Front. Oncol. 2023, 13:1178634. doi: 10.3389/fonc.2023.1178634
-Deciphering miRNA–Target Relationships to Understand miRNA-Mediated Carcinogenesis. A Navarro. Cancers 2021, 13(10), 2415.
-Editorial: The Role of ncRNAs in Solid Tumors Prognosis: From Laboratory to Clinical Utility.. Zhou J-G, Huang Z, Slaby O and Navarro A Front. Oncol. 2021, 10:631316.
-Clinic and therapeutic potential of non-coding RNAs in cancer. JJ Castellano, M Diaz-Beya, A Navarro. Transl Cancer Res 10 (6).
-Can long non-coding RNAs reveal the hidden code of lung cancer?. JJ Castellano, A Navarro. Non-coding RNA Investigation, 2020, vol. 4, num. 6.
-Twist1 activated circRNA-10720 is a new player in hepatocellular carcinoma metastasis. A Navarro. Transl Cancer Res 8 (S2), S135-S140.
-Argonaute-crosslinking and immunoprecipitation deciphers the liver miR-122 targetome. A Navarro. Non-coding RNA Investig 1, 23.
-Genotypes and chemotherapy toxicity. M Monzo, A Navarro. Pharmacogenomics vol. 10, num. 3.
-Genetic Predictors of Leukocytopenia severity. M Monzo, A Navarro. Pharmacogenomics vol. 10, num. 3.
-Interview with Dr. Alfons Navarro: non-coding RNAs as cancer biomarkers. Alfons Navarro, Lily Yu, Margo Y. Chen. Translational Cancer Research. Posted On 2024-07-08.
-miR-34a as a prognostic marker of relapse in surgically resected non-small-cell lung cancer. E Gallardo, A Navarro, N Vinolas, RM Marrades, T Diaz, B Gel, A Quera, … Carcinogenesis 30 (11), 1903-1909.
-Overlapping expression of microRNAs in human embryonic colon and colorectal cancer. M Monzo, A Navarro, E Bandres, R Artells, I Moreno, B Gel, R Ibeas, … Cell research 18 (8), 823-833.
-MicroRNA expression profiling in classic Hodgkin lymphoma. A Navarro, A Gaya, A Martinez, A Urbano-Ispizua, A Pons, O Balagué, … Blood, The Journal of the American Society of Hematology 111 (5), 2825-2832.
-Regulation of JAK2 by miR-135a: prognostic impact in classic Hodgkin lymphoma. A Navarro, T Diaz, A Martinez, A Gaya, A Pons, B Gel, C Codony, G Ferrer, … Blood, The Journal of the American Society of Hematology 114 (14), 2945-2951.
-Acute myeloid leukemia with translocation (8; 16)(p11; p13) and MYST3-CREBBP rearrangement harbors a distinctive microRNA signature targeting RET proto-oncogene. M Diaz-Beya, A Navarro, G Ferrer, T Diaz, B Gel, M Camos, M Pratcorona, … Leukemia 27 (3), 595-603.
-MicroRNA expression at diagnosis adds relevant prognostic information to molecular categorization in patients with intermediate-risk cytogenetic acute myeloid leukemia. M Diaz-Beya, S Brunet, J Nomdedeu, R Tejero, T Diaz, M Pratcorona, … Leukemia 28 (4), 804-812
-LincRNA-p21 impacts prognosis in resected non–small cell lung Cancer patients through angiogenesis regulation. JJ Castellano, A Navarro, N Viñolas, RM Marrades, J Moises, A Cordeiro, … Journal of Thoracic Oncology 11 (12), 2173-2182.
-PiwiRNA-651 as marker of treatment response and survival in classical Hodgkin lymphoma. A Cordeiro, A Navarro, A Gaya, M Díaz-Beyá, B Gonzalez-Farré, … Oncotarget 7 (29), 46002-46013.
-The significance of PIWI family expression in human lung embryogenesis and non-small cell lung cancer. A Navarro, R Tejero, N Viñolas, A Cordeiro, RM Marrades, D Fuster, … Oncotarget 6 (31), 31544.
-Role of the epithelial-mesenchymal transition-related circular RNA, circ-10720, in non-small-cell lung cancer. J Martín, JJ Castellano, RM Marrades, J Canals, N Viñolas, T Díaz, … Translational Lung Cancer Research 10 (4), 1804
-Extracellular vesicle lincRNA-p21 expression in tumor-draining pulmonary vein defines prognosis in NSCLC and modulates endothelial cell behavior. JJ Castellano, RM Marrades, L Molins, N Viñolas, J Moises, J Canals, … Cancers 12 (3), 734
-Exosome analysis in tumor-draining pulmonary vein identifies NSCLC patients with higher risk of relapse after curative surgery. A Navarro, L Molins, RM Marrades, J Moises, N Viñolas, S Morales, … Cancers 11 (2), 249
-Impact of MiRSNPs on survival and progression in patients with multiple myeloma undergoing autologous stem cell transplantation. CF de Larrea, A Navarro, R Tejero, N Tovar, T Díaz, MT Cibeira, L Rosinol, … Clinical cancer research 18 (13), 3697-3704.
-Genomic polymorphisms provide prognostic information in intermediate-risk acute myeloblastic leukemia. M Monzo, S Brunet, A Urbano-Ispizua, A Navarro, G Perea, J Esteve, … Blood 107 (12), 4871-4879.
-MiR-SNPs as markers of toxicity and clinical outcome in Hodgkin lymphoma patients. A Navarro, C Munoz, A Gaya, M Díaz-Beyá, B Gel, R Tejero, T Díaz, … PloS one 8 (5), e64716
-A dual role for KRT81: a miR-SNP associated with recurrence in non-small-cell lung cancer and a novel marker of squamous cell lung carcinoma. M Campayo, A Navarro, N Vinolas, R Tejero, C Munoz, T Diaz, … PloS one 6 (7), e22509
-Single-nucleotide polymorphisms in base excision repair, nucleotide excision repair, and double strand break genes as markers for response to radiotherapy in patients with stage I to II head-and-neck cancer. J Carles, M Monzo, M Amat, S Jansa, R Artells, A Navarro, P Foro, … International Journal of Radiation Oncology* Biology* Physics 66 (4), 1022-1030.
-Common variants in NLRP2 and NLRP3 genes are strong prognostic factors for the outcome of HLA-identical sibling allogeneic stem cell transplantation. M Granell, A Urbano-Ispizua, A Pons, JI Aróstegui, B Gel, A Navarro, … Blood, The Journal of the American Society of Hematology 112 (10), 4337-4342